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Review
, 21 (4), 613-35

The Prevalence and Incidence of Helicobacter Pylori-Associated Peptic Ulcer Disease and Upper Gastrointestinal Bleeding Throughout the World

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Review

The Prevalence and Incidence of Helicobacter Pylori-Associated Peptic Ulcer Disease and Upper Gastrointestinal Bleeding Throughout the World

Andrew Y Wang et al. Gastrointest Endosc Clin N Am.

Abstract

Due to heightened awareness regarding testing for and eradication of infection, the prevalence and incidence of H pylori infection (and by extension the prevalence and incidence of peptic ulcer disease) appear to have declined in recent years. However, antimicrobial resistance is mounting and traditional clarithromycin- or metronidazole-containing triple therapies may no longer be highly effective at eradicating the infection. Combined bismuth- and metronidazole-containing quadruple therapy or sequential 4-drug therapy may be better choices for first-line treatment against this unique pathogen that is ideally suited to survive in the human stomach.

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