Correction of an unexpected increasing trend in glucose measurements during 7 years recruitment to a cohort study

K F Frøslie; K Godang; J Bollerslev; T Henriksen; J Røislien; M B Veierød; E Qvigstad

doi:10.1016/j.clinbiochem.2011.08.1150

Correction of an unexpected increasing trend in glucose measurements during 7 years recruitment to a cohort study

Clin Biochem. 2011 Dec;44(17-18):1483-6. doi: 10.1016/j.clinbiochem.2011.08.1150. Epub 2011 Sep 16.

Authors

K F Frøslie¹, K Godang, J Bollerslev, T Henriksen, J Røislien, M B Veierød, E Qvigstad

Affiliation

¹ Norwegian Resource Centre for Women's Health, Division of Obstetrics and Gynaecology, Oslo University hospital Rikshospitalet, Norway. k.f.froslie@medisin.uio.no

PMID: 21945023
DOI: 10.1016/j.clinbiochem.2011.08.1150

Abstract

Objectives: To study an unexpected, significant increase in glucose measurements during 7 year recruitment to a cohort study.

Design and methods: Measurements of quality control solutions and blood glucose in pregnant women were done by Accu-Chek Sensor glucometer. Time-trends were analysed by regression models and control charts.

Results: Cohort measurements were de-trended by weighted linear regressions based on independent control values.

Conclusions: Biologically implausible trends in data can be corrected by using independent control values.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blood Glucose*
Cohort Studies
Confidence Intervals
Data Interpretation, Statistical
Diagnostic Equipment / standards*
Female
Glucose Tolerance Test / standards*
Humans
Pregnancy
Quality Control
Reference Standards
Regression Analysis

Substances

Blood Glucose