Impact of maternal probiotic-supplemented dietary counseling during pregnancy on colostrum adiponectin concentration: a prospective, randomized, placebo-controlled study

Early Hum Dev. 2012 Jun;88(6):339-44. doi: 10.1016/j.earlhumdev.2011.09.006. Epub 2011 Sep 25.


Background: The breast milk bioactive substances such as adiponectin, have a presumably long-term impact upon the health and well-being of a child.

Aim: To determine the impact of probiotic-supplemented dietary counseling during pregnancy on colostrum adiponectin concentration.

Study design and subjects: Altogether 256 pregnant women were randomized into three study groups: dietary intervention with probiotics (diet/probiotics) or with placebo (diet/placebo) and a control group (control/placebo). The intervention group received dietary counseling provided by a nutritionist, the main focus being the amount and the type of dietary fat. The probiotics used were Lactobacillus rhamnosus GG and Bifidobacterium lactis in combination. Dietary intake was evaluated by food records at every trimester of pregnancy. Breast milk samples were collected after birth (colostrum) for adiponectin concentration analysis (n=181).

Results: The dietary intervention increased the colostrum adiponectin concentration (ng/mL, geometric mean [95% CI]), the difference being significant when comparing to the control group; 12.7 [10.6-29.7] vs. 10.2 [9.9-13.2], P=0.024. Maternal weight gain during pregnancy (kg) correlated inversely with colostrum adiponectin concentration; β (SE)=-1.7 (0.1), P=0.020, and gestational diabetes mellitus was associated with the likelihood of adiponectin concentration falling into the lowest quartile; OR 2.36, 95% CI 1.1-3.2, P=0.028.

Conclusions: In showing that the colostrum adiponectin concentration is markedly dependent on maternal diet and nutritional status during pregnancy, and considering that colostrum adiponectin has potential effects on metabolism, nutrition, and immune function in the neonates, the results of this study underscore the importance of the metabolic homeostasis of the mother for the child's initial nutritional environment.

Trial registration: NCT00167700.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / metabolism*
  • Adolescent
  • Adult
  • Bifidobacterium
  • Colostrum / drug effects*
  • Colostrum / metabolism
  • Diet*
  • Directive Counseling / methods*
  • Female
  • Health Behavior
  • Humans
  • Lactobacillus rhamnosus
  • Maternal Nutritional Physiological Phenomena*
  • Pregnancy
  • Pregnancy Outcome
  • Probiotics / administration & dosage*
  • Probiotics / therapeutic use
  • Prospective Studies
  • Young Adult


  • Adiponectin

Associated data