Protein kinase C and tumor promoters

Curr Opin Cell Biol. 1990 Apr;2(2):192-7. doi: 10.1016/0955-0674(90)90006-z.


The complexity of PKC has made it difficult to define the precise biochemical processes associated with the various PKC-related cellular responses observed. In the past year, we have seen progress in complementary approaches that are helping to solve the puzzles. These include purification and characterization of individual isozymes, expression of normal and mutant PKCs, immunolocalization, and identification of specific activators and inhibitors. All of these will be useful in identifying the primary targets of PKC phosphorylation and their function.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division / drug effects
  • Cell Division / physiology*
  • Humans
  • Isoenzymes / physiology
  • Phorbol Esters / pharmacology
  • Protein Kinase C / antagonists & inhibitors
  • Protein Kinase C / physiology*
  • Protein Processing, Post-Translational
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Structure-Activity Relationship
  • Subcellular Fractions / enzymology


  • Isoenzymes
  • Phorbol Esters
  • Protein Kinase C