Efficacy of diphenhydramine in the prevention of vertigo and nausea at 7 T MRI

Eur J Radiol. 2013 May;82(5):768-72. doi: 10.1016/j.ejrad.2011.08.001. Epub 2011 Sep 25.


Purpose: In this study the potential of diphenhydramine in reducing respectively preventing vertigo and nausea induced by the ultra-high static magnetic field at 7 T was evaluated.

Materials and methods: In a prospective, double blinded, placebo controlled, cross-over randomized study the sensations of 34 volunteers before, during and after exposure to the static magnetic field with and without drug respectively placebo administration were quantified. Fast table motion was applied to increase the incidence of otherwise sparse reports of field related sensations.

Results: The strength of vertigo can be reduced by the application of diphenhydramine.

Conclusion: Diphenhydramine, even at a low dose, reduces the strength of vertigo at ultra-high static magnetic fields, may be used preventively, and could pave the way to even higher field strength.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Diphenhydramine / administration & dosage*
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Humans
  • Hypnotics and Sedatives / therapeutic use
  • Magnetic Fields / adverse effects*
  • Magnetic Resonance Imaging / adverse effects*
  • Male
  • Middle Aged
  • Nausea / diagnosis
  • Nausea / etiology*
  • Nausea / prevention & control*
  • Placebo Effect
  • Prospective Studies
  • Treatment Outcome
  • Vertigo / diagnosis
  • Vertigo / etiology*
  • Vertigo / prevention & control*


  • Hypnotics and Sedatives
  • Diphenhydramine