The cell biology of transforming growth factor beta

Biochim Biophys Acta. 1990 Jun 1;1032(1):79-87. doi: 10.1016/0304-419x(90)90013-q.


The TGF beta family of polypeptide growth factors regulates a remarkable diversity of cellular functions, many of which are not directly associated with cell growth. The present review has summarized many of the recent studies that have just begun to conceptually integrate this expanding array of TGF beta functions into the context of a three-dimensional, multicellular organ or tissue, be it normal or diseased. This fascinating research strongly implicates TGF beta as a key modulator of a wide variety of important physiologic and pathophysiologic processes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Division
  • Cell Physiological Phenomena*
  • Humans
  • Transforming Growth Factors / physiology*


  • Transforming Growth Factors