Remodeling of the neuronal circuits underlying opiate-withdrawal memories following remote retrieval

Neurobiol Learn Mem. 2012 Jan;97(1):47-53. doi: 10.1016/j.nlm.2011.09.002. Epub 2011 Sep 16.


Several types of memory display time-dependent reorganization of their underlying neural substrates, but it remains unclear whether affective memories associated with drug effects also follow similar reorganization. Here, we analyzed the neural circuits reactivated by the re-exposure of former dependent rats to the withdrawal-paired environment 1month after conditioning (remote memory) as compared with recent memory (Frenois, F., Stinus, L., Di Blasi, F., Cador, M., & Le Moine, C. (2005) A specific limbic circuit underlies opiate withdrawal memories The Journal of Neuroscience, 25, 1366-1374). C-fos expression showed that the circuits involved in the retrieval of withdrawal memories are partly different when comparing recent and remote reactivation, showing that, like other type of memories, affective memories linked to opiate withdrawal undergo anatomical reorganization, with a shift from extended amygdala regions toward cortical areas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Conditioning, Psychological / drug effects
  • Conditioning, Psychological / physiology*
  • Cues
  • Male
  • Memory / drug effects
  • Memory / physiology*
  • Morphine / administration & dosage*
  • Narcotics / administration & dosage*
  • Nerve Net / drug effects
  • Nerve Net / physiology*
  • Neurons / drug effects
  • Neurons / physiology*
  • Rats
  • Rats, Sprague-Dawley


  • Narcotics
  • Morphine