The role of lipoprotein receptors on the physiological function of APP

Exp Brain Res. 2012 Apr;217(3-4):377-87. doi: 10.1007/s00221-011-2876-8. Epub 2011 Sep 23.


In this review, we will primarily focus on the role of members of the low-density lipoprotein receptor (LDL-R) family that are involved in trafficking and processing of the amyloid precursor protein (APP). We will discuss the role of the LDL-receptor family members, low-density lipoprotein receptor-related protein 1 (LRP1), LRP1b, apolipoprotein E receptor 2, sortilin-related receptor (SorLA/LR11) and megalin/LRP2 on the physiological function of APP and its cellular localization. Additionally, we will focus on adaptor proteins that have been shown to influence the physiological function of LDL-R family members in combination with APP processing. The results in this review emphasize that the physiological function of APP cannot be explained by the focus on the APP protein alone but rather in combination with various direct or indirect interaction partners within the cellular environment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amyloid beta-Protein Precursor / metabolism
  • Amyloid beta-Protein Precursor / physiology*
  • Animals
  • Cell Communication / physiology*
  • Humans
  • Protein Transport / physiology
  • Receptors, LDL / physiology*
  • Receptors, Lipoprotein / physiology*


  • Amyloid beta-Protein Precursor
  • Receptors, LDL
  • Receptors, Lipoprotein