IL-23 in infections, inflammation, autoimmunity and cancer: possible role in HIV-1 and AIDS

J Neuroimmune Pharmacol. 2012 Mar;7(1):95-112. doi: 10.1007/s11481-011-9315-2. Epub 2011 Sep 24.


The growing family of interleukin (IL)-12-like cytokines produced by activated macrophages and dendritic cells became the important players in the control of infections, development of inflammation, autoimmunity and cancer. However, the role of one of them-heterodimer IL-23, which consists of IL12p40 and the unique p19 subunit in HIV-1 infection pathogenesis and progression to AIDS, represent special interest. We overviewed findings of IL-23 involvement in control of peripheral bacterial pathogens and opportunistic infection, central nervous system (CNS) viral infections and autoimmune disorders, and tumorogenesis, which potentially could be applicable to HIV-1 and AIDS.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology*
  • Acquired Immunodeficiency Syndrome / metabolism
  • Animals
  • Autoimmune Diseases / immunology
  • Autoimmunity / immunology*
  • Communicable Diseases / immunology
  • HIV-1 / immunology*
  • Humans
  • Inflammation / immunology*
  • Inflammation / metabolism
  • Interleukin-23 / immunology*
  • Interleukin-23 / metabolism
  • Neoplasms / immunology*
  • Neoplasms / metabolism


  • Interleukin-23