The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore

J Clin Invest. 1990 Jul;86(1):279-85. doi: 10.1172/JCI114696.

Abstract

We have recently reported a new family of nuclear autoantibodies in a subset of patients with primary biliary cirrhosis. These antibodies bind to a nuclear envelope polypeptide(s) of approximately 200 kD, the exact identity of which was not established. In this study, we show that all of these autoantibodies are directed against a 210-kD integral membrane glycoprotein of the nuclear pore.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Autoantigens / immunology*
  • Blotting, Western
  • Fluorescent Antibody Technique
  • Humans
  • Liver Cirrhosis, Biliary / immunology*
  • Membrane Glycoproteins / immunology*
  • Molecular Weight
  • Nuclear Envelope / immunology*
  • Nuclear Proteins / immunology*
  • Precipitin Tests

Substances

  • Autoantigens
  • Membrane Glycoproteins
  • Nuclear Proteins