Molecular mechanisms of Barrett's esophagus and adenocarcinoma

Ann N Y Acad Sci. 2011 Sep;1232:381-91. doi: 10.1111/j.1749-6632.2011.06062.x.

Abstract

The following on molecular mechanisms of Barrett's esophagus and adenocarcinoma contains commentaries on the mechanism of bile and gastric acid induced damage; the roles of BMP-4 and CDX-2 in the development of intestinal metaplasia; the transcription factors driving intestinalization in Barrett's esophagus; the contribution of bone marrow to metaplasia and adenocarcinoma; activation and inactivation of transcription factors; and a novel study design targeting molecular pathways in Barrett's esophagus.

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma / physiopathology
  • Barrett Esophagus / genetics*
  • Barrett Esophagus / physiopathology
  • Bile Acids and Salts / physiology
  • Bone Morphogenetic Protein 4 / physiology
  • CDX2 Transcription Factor
  • DNA Damage
  • Esophageal Neoplasms / genetics*
  • Esophageal Neoplasms / physiopathology
  • Homeodomain Proteins / physiology
  • Humans
  • Trans-Activators / physiology

Substances

  • Bile Acids and Salts
  • Bone Morphogenetic Protein 4
  • CDX2 Transcription Factor
  • Homeodomain Proteins
  • Trans-Activators