Tumor-to-tumor metastasis: Hepatocellular carcinoma metastatic to parathyroid adenoma

Pathol Int. 2011 Oct;61(10):593-7. doi: 10.1111/j.1440-1827.2011.02707.x. Epub 2011 Aug 4.


Tumor-to-tumor metastasis is a rare, but well-recognized phenomenon. Here, we report a unique case of hepatocellular carcinoma (HCC) metastatic to parathyroid adenoma. A 53-year-old-man with a history of HCC presented with hypercalcemia. It was found that he also had hyperparathyroidism with a hypoechoic mass in the lower portion of the right thyroid gland area. The patient underwent parathyroidectomy, and a mass measuring 1.5 × 1.0 cm was detected. Microscopic and immunohistochemical examination disclosed parathyroid adenoma with a focus of metastatic HCC. For the patient, it was the only distant metastasis revealed until the last follow-up. To the best of our knowledge, this is the first reported case of tumor-to-tumor metastasis in which HCC is the donor.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / metabolism
  • Adenoma / pathology*
  • Adenoma / therapy
  • Carcinoma, Hepatocellular / metabolism
  • Carcinoma, Hepatocellular / secondary*
  • Catheter Ablation / methods
  • Chemoembolization, Therapeutic / methods
  • Humans
  • Incidental Findings
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / pathology*
  • Liver Neoplasms / secondary
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Parathyroid Neoplasms / metabolism
  • Parathyroid Neoplasms / secondary*
  • Parathyroid Neoplasms / therapy
  • Parathyroidectomy