Vaccines for colorectal cancer and renal cell carcinoma

Cancer J. 2011 Sep-Oct;17(5):283-93. doi: 10.1097/PPO.0b013e318232ff44.


Vaccines have shown promise for the prevention and treatment of solid tumors. Colorectal cancer and renal cell carcinoma are common malignancies that may be amenable to vaccine strategies. This review summarizes target antigens in colorectal and renal cell carcinoma, discusses some of the vaccine approaches in development, and details the results of pivotal phase III trials evaluating therapeutic vaccines in patients with advanced colorectal and renal cell carcinoma. Finally, some of the challenges with vaccine development for colorectal and renal cell carcinoma are described.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Neoplasm
  • Cancer Vaccines / immunology*
  • Cancer Vaccines / therapeutic use*
  • Carcinoembryonic Antigen / genetics
  • Carcinoembryonic Antigen / immunology
  • Carcinoma, Renal Cell / immunology*
  • Carcinoma, Renal Cell / therapy*
  • Clinical Trials as Topic
  • Colorectal Neoplasms / immunology*
  • Colorectal Neoplasms / therapy*
  • Humans
  • Kidney Neoplasms / immunology*
  • Kidney Neoplasms / therapy*
  • Mice
  • Mice, Transgenic
  • Mucin-1 / immunology
  • Mucin-1 / metabolism
  • Vaccines, DNA / immunology


  • Antigens, Neoplasm
  • Cancer Vaccines
  • Carcinoembryonic Antigen
  • Mucin-1
  • Vaccines, DNA