Relationship between recurrent miscarriage and insulin resistance

Gynecol Obstet Invest. 2011;72(4):245-51. doi: 10.1159/000325165. Epub 2011 Sep 24.


Aims: To investigate the differences in insulin resistance between women with recurrent miscarriage and those with normal pregnancy.

Methods: Pregnant women with a history of recurrent miscarriage were included in the patient group (n = 97), while those with no history of abnormal pregnancy were included in the control group (n = 52). Both groups consented to undertake an oral glucose tolerance test and insulin-releasing test between the 5th and 13th weeks of pregnancy.

Results: (1) Levels of fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance index, and homeostasis model assessment β function were not statistically significantly different (p < 0.05) between the two groups. (2) The area under the curve of glucose and area under the curve of insulin were higher in the patient group than in the control group. The composite insulin sensitivity index of the patient group was lower than that of the control group. The differences in these three parameters between the groups were statistically significant (p < 0.05).

Conclusion: Women with a history of recurrent miscarriage are at an increased risk for insulin resistance during the first trimester of a new pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Habitual / physiopathology*
  • Adult
  • Blood Glucose
  • Case-Control Studies
  • Female
  • Glucose Tolerance Test
  • Humans
  • Insulin / blood
  • Insulin Resistance / physiology*
  • Pregnancy
  • Pregnancy Trimester, First / physiology*
  • Risk Factors
  • Young Adult


  • Blood Glucose
  • Insulin