F4/80 and the related adhesion-GPCRs

Eur J Immunol. 2011 Sep;41(9):2472-6. doi: 10.1002/eji.201141715.


The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805-815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF-TM7 family, as part of a larger family of tissue adhesion-GPCRs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / immunology
  • Antigens, Differentiation / immunology*
  • Antigens, Differentiation / metabolism
  • Biomarkers / metabolism
  • Cell Adhesion / immunology
  • Cell Differentiation
  • Humans
  • Macrophages / immunology*
  • Mice
  • Monocytes / immunology*
  • Receptors, G-Protein-Coupled / immunology*


  • ADGRE2 protein, human
  • ADGRE5 protein, human
  • Antigens, CD
  • Antigens, Differentiation
  • Biomarkers
  • Receptors, G-Protein-Coupled
  • monocyte-macrophage differentiation antigen