Exhaustive fluorine scanning toward potent p53-Mdm2 antagonists

ChemMedChem. 2012 Jan 2;7(1):49-52. doi: 10.1002/cmdc.201100428. Epub 2011 Sep 27.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzene Derivatives / chemistry
  • Benzene Derivatives / pharmacology
  • Drug Discovery
  • Fluorine / chemistry*
  • Fluorine / pharmacology*
  • Humans
  • Models, Molecular
  • Protein Binding / drug effects
  • Proto-Oncogene Proteins c-mdm2 / antagonists & inhibitors*
  • Proto-Oncogene Proteins c-mdm2 / metabolism
  • Tumor Suppressor Protein p53 / antagonists & inhibitors*
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Benzene Derivatives
  • Tumor Suppressor Protein p53
  • Fluorine
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2