Ginger phytochemicals mitigate the obesogenic effects of a high-fat diet in mice: a proteomic and biomarker network analysis

Mol Nutr Food Res. 2011 Sep:55 Suppl 2:S203-13. doi: 10.1002/mnfr.201100193. Epub 2011 Aug 30.


Scope: Natural dietary anti-obesogenic phytochemicals may help combat the rising global incidence of obesity. We aimed to identify key hepatic pathways targeted by anti-obsogenic ginger phytochemicals fed to mice.

Methods and results: Weaning mice were fed a high-fat diet containing 6-gingerol (HFG), zerumbone (HFZ), a characterized rhizome extract of the ginger-related plant Alpinia officinarum Hance (high fat goryankang, HFGK) or no phytochemicals (high-fat control, HFC) for 6 wks and were compared with mice on a low-fat control diet (LFC). Increased adiposity in the HFC group, compared with the LFC group, was significantly (p<0.05) reduced in the HFG and HFGK groups without food intake being affected. Correlation network analysis, including a novel residuals analysis, was utilized to investigate relationships between liver proteomic data, lipid and cholesterol biomarkers and physiological indicators of adiposity. 6-Gingerol significantly increased plasma cholesterol but hepatic farnesyl diphosphate synthetase, which is involved in cholesterol biosynthesis was decreased, possibly by negative feedback. Acetyl-coenzyme A acyltransferase 1 and enoyl CoA hydratase, which participate in the β-oxidation of fatty acids were significantly (p<0.05) increased by consumption of phytochemical-supplemented diets.

Conclusion: Dietary ginger phytochemicals target cholesterol metabolism and fatty acid oxidation in mice, with anti-obesogenic but also hypercholesterolemic consequences.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetyl-CoA C-Acyltransferase / metabolism
  • Adiposity / drug effects
  • Alpinia / chemistry
  • Animals
  • Anti-Obesity Agents / pharmacology*
  • Biomarkers / analysis*
  • Body Weight / drug effects
  • Catechols / pharmacology
  • Cholesterol / blood
  • Diet, Fat-Restricted
  • Diet, High-Fat*
  • Enoyl-CoA Hydratase / metabolism
  • Fatty Alcohols / pharmacology
  • Geranyltranstransferase / metabolism
  • Liver / drug effects
  • Liver / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Plant Extracts / pharmacology
  • Principal Component Analysis
  • Proteins / metabolism*
  • Proteomics
  • Sesquiterpenes / pharmacology
  • Zingiber officinale / chemistry*


  • Anti-Obesity Agents
  • Biomarkers
  • Catechols
  • Fatty Alcohols
  • Plant Extracts
  • Proteins
  • Sesquiterpenes
  • zerumbone
  • gingerol
  • Cholesterol
  • Acetyl-CoA C-Acyltransferase
  • Geranyltranstransferase
  • Enoyl-CoA Hydratase