[Regulation of multidrug resistance genes by transcriptional factors from the BltR subfamily]

Mol Biol (Mosk). Jul-Aug 2011;45(4):715-23.
[Article in Russian]

Abstract

BltR is a MerR family transcriptional factor, experimentally characterized in Bacillus subtilis. It activates transcription of genes encoding multidrug transporter Blt and spermine/spermidine acetyltransferase BltD. Here we studied BltR dependent regulons in 25 bacterial genomes using the comparative genomic approach. The structure of the promoter regions of regulated genes is typical for MerR family activators: the binding sites are located in long spacers between promoter elements. Regulated genes are usually co-localized with regulator genes and are divergently transcribed with them. The studied transcriptional factors regulate the transcription of multidrug transporter and spermine/spermidine acetyltransferase genes. These transporters can be either secondary or ATP-dependent. The phylogenetic analysis demonstrated that their role as multidrug transporters is conserved.

Publication types

  • English Abstract

MeSH terms

  • Acetyltransferases / genetics
  • Acetyltransferases / metabolism
  • Bacillus subtilis / genetics
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Binding Sites / genetics
  • Computational Biology
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Gene Expression Regulation, Bacterial*
  • Genome, Bacterial*
  • Multigene Family / genetics
  • Phylogeny
  • Promoter Regions, Genetic / genetics
  • Regulon / genetics*
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*

Substances

  • Bacterial Proteins
  • BltR protein, Bacillus subtilis
  • DNA-Binding Proteins
  • MerR protein, Bacteria
  • Trans-Activators
  • Blt protein, Bacillus subtilis
  • Acetyltransferases
  • BltD protein, Bacillus subtilis