The use of dabigatran immediately after atrial fibrillation ablation

J Cardiovasc Electrophysiol. 2012 Mar;23(3):264-8. doi: 10.1111/j.1540-8167.2011.02175.x. Epub 2011 Sep 28.


Introduction: Atrial fibrillation (AF) ablation requires postprocedural anticoagulation to prevent thromboembolic events because of the ablation procedure itself or due to recurrent AF postprocedure. Dabigatran is a new anticoagulant and may be useful after AF ablation to prevent thromboembolic events.

Methods and results: We evaluated 123 consecutive patients who were started on dabigatran after AF ablation. Patients were given enoxaparin 0.5 mg/kg at the end of the procedure, which was repeated 12 hours later and then discontinued. Dabigatran was started 22 hours postablation with drug dose based on renal function. Primary outcomes were thromboembolic events, bleeding complications, and side effects over a 30-day follow-up period. The preablation anticoagulant was warfarin in 56 (45.5%) patients, dabigatran in 34 (27.6%), and aspirin in 26 (21.1%). Seven (5.7%) patients were on no anticoagulant before ablation. The patients on dabigatran before ablation with normal renal function had the drug stopped 36 hours preablation. There were no preprocedural or intraprocedural thromboembolic episodes or bleeding. Three patients received dabigatran 75 mg bid and the rest 150 mg bid. There were no postablation strokes, transient ischemic attacks, or systemic thromboemboli in any patient. Three patients discontinued dabigatran and were changed to warfarin, 2 because of gastrointestinal side effects and 1 because of a diffuse rash.

Conclusions: Dabigatran is safe and well tolerated after AF ablation. It did not cause bleeding complications and there were no thromboembolic events. Dabigatran appears to be an alternative to warfarin after AF ablation.

MeSH terms

  • Aged
  • Anticoagulants / adverse effects
  • Anticoagulants / therapeutic use*
  • Aspirin / adverse effects
  • Aspirin / therapeutic use
  • Atrial Fibrillation / drug therapy*
  • Atrial Fibrillation / surgery*
  • Benzimidazoles / adverse effects
  • Benzimidazoles / therapeutic use*
  • Catheter Ablation*
  • Dabigatran
  • Drug Tolerance
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate
  • Hemorrhage / complications
  • Hemorrhage / etiology
  • Humans
  • Male
  • Middle Aged
  • Platelet Aggregation Inhibitors / adverse effects
  • Platelet Aggregation Inhibitors / therapeutic use
  • Retrospective Studies
  • Thrombin / antagonists & inhibitors
  • Thromboembolism / prevention & control
  • Treatment Outcome
  • Warfarin / adverse effects
  • Warfarin / therapeutic use
  • beta-Alanine / adverse effects
  • beta-Alanine / analogs & derivatives*
  • beta-Alanine / therapeutic use


  • Anticoagulants
  • Benzimidazoles
  • Platelet Aggregation Inhibitors
  • beta-Alanine
  • Warfarin
  • Thrombin
  • Dabigatran
  • Aspirin