Symmetry breaking and the establishment of cell polarity in budding yeast

Curr Opin Genet Dev. 2011 Dec;21(6):740-6. doi: 10.1016/j.gde.2011.09.007. Epub 2011 Sep 28.

Abstract

Cell polarity is typically oriented by external cues such as cell-cell contacts, chemoattractants, or morphogen gradients. In the absence of such cues, however, many cells can spontaneously polarize in a random direction, suggesting the existence of an internal polarity-generating mechanism whose direction can be spatially biased by external cues. Spontaneous 'symmetry-breaking' polarization is likely to involve an autocatalytic process set off by small random fluctuations. Here we review recent work on the nature of the autocatalytic process in budding yeast and on the question of why polarized cells only develop a single 'front'.

Publication types

  • Review

MeSH terms

  • Actins / metabolism
  • Cell Differentiation
  • Cell Membrane / metabolism
  • Cell Polarity*
  • Models, Biological
  • Morphogenesis
  • Multigene Family
  • Saccharomycetales / cytology*
  • Saccharomycetales / metabolism
  • Systems Biology
  • cdc42 GTP-Binding Protein, Saccharomyces cerevisiae / genetics
  • cdc42 GTP-Binding Protein, Saccharomyces cerevisiae / metabolism

Substances

  • Actins
  • cdc42 GTP-Binding Protein, Saccharomyces cerevisiae