Pristine C(60) fullerenes inhibit the rate of tumor growth and metastasis

Exp Oncol. 2011 Sep;33(3):162-4.


Aim: To estimate the impact of C(60) fullerene aqueous solution (C(60)FAS) on the rate of transplanted malignant tumor growth and metastasis.

Methods: Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been used.

Results: The C(60)FAS at low single therapeutic dose of 5 mg/kg inhibited the growth of transplanted malignant tumor (antitumor effect) and metastasis (antimetastatic effect): the maximum therapeutic effect was found to be of 76.5% for the tumor growth inhibition; the increase of animal life span by 22% was found; the metastasis inhibition index was estimated as 48%.

Conclusion: It was found that water-soluble pristine С(60) fullerenes efficiently inhibit the transplanted malignant tumor growth and metastasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Carcinoma, Lewis Lung / drug therapy*
  • Carcinoma, Lewis Lung / pathology*
  • Carcinoma, Lewis Lung / secondary
  • Cell Proliferation / drug effects
  • Fullerenes / pharmacology*
  • Fullerenes / therapeutic use
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Neoplasm Metastasis / drug therapy
  • Neoplasm Transplantation


  • Antineoplastic Agents
  • Fullerenes
  • pristine (C60)