Α-pyrones and diketopiperazine derivatives from the marine-derived actinomycete Nocardiopsis dassonvillei HR10-5

Peng Fu; Peipei Liu; Haijun Qu; Yi Wang; Dianfeng Chen; Hui Wang; Jing Li; Weiming Zhu

doi:10.1021/np200597m

Α-pyrones and diketopiperazine derivatives from the marine-derived actinomycete Nocardiopsis dassonvillei HR10-5

J Nat Prod. 2011 Oct 28;74(10):2219-23. doi: 10.1021/np200597m. Epub 2011 Sep 29.

Authors

Peng Fu¹, Peipei Liu, Haijun Qu, Yi Wang, Dianfeng Chen, Hui Wang, Jing Li, Weiming Zhu

Affiliation

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, and Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, People's Republic of China.

PMID: 21958359
DOI: 10.1021/np200597m

Abstract

Three new α-pyrones, nocapyrones E-G (1-3), and three new diketopiperazine derivatives, nocazines A-C (4-6), together with a new oxazoline compound, nocazoline A (7), were isolated from the marine-derived actinomycete Nocardiopsis dassonvillei HR10-5. The new structures of 1-7 were determined by spectroscopic analysis, X-ray single-crystal diffraction, CD spectra, and modified Mosher and Marfey methods. Compounds 1-3 showed modest antimicrobial activity against Bacillus subtilis with MIC values of 26, 14, and 12 μM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actinobacteria / chemistry*
Anti-Bacterial Agents / chemistry*
Bacillus subtilis / drug effects
Diketopiperazines / chemistry
Diketopiperazines / isolation & purification*
Diketopiperazines / pharmacology
Drug Screening Assays, Antitumor
Marine Biology
Microbial Sensitivity Tests
Molecular Structure
Oxazoles / chemistry
Oxazoles / isolation & purification*
Oxazoles / pharmacology
Pyrones / chemistry
Pyrones / isolation & purification*
Pyrones / pharmacology

Substances

Anti-Bacterial Agents
Diketopiperazines
Oxazoles
Pyrones