Effect of prior cardiac operations on survival after coronary artery bypass grafting

Ann Thorac Surg. 2011 Oct;92(4):1260-7. doi: 10.1016/j.athoracsur.2011.05.111.


Background: We examined a recent regional experience to determine the effect of a prior cardiac operation on short-term and midterm outcomes after coronary artery bypass grafting (CABG).

Methods: We identified 20,703 patients who underwent nonemergent CABG at 8 centers in northern New England from 2000 to 2008, of whom 818 (3.8%) had undergone prior cardiac operations. Prior CABG using a minimal or full sternotomy was considered a prior sternotomy. Survival data out to 4 years were obtained from a link with the Social Security Administration Death Index. Hazard ratios were estimated using a Cox proportional hazards regression model, and adjusted survival curves were estimated using inverse probability weighting. In a separate analysis, 1,182 patients were matched 1:1 by a patient's propensity for having undergone prior CABG.

Results: Patients with prior sternotomies had a greater burden of comorbid diseases and increased acuity and had a greater likelihood of returning to the operating room for bleeding and low cardiac output failure. Prior sternotomy was associated with an increased risk of death out to 4 years for patients undergoing CABG, with an unmatched hazard ratio of 1.34 (95% confidence interval, 1.10 to 1.64) and a matched hazard ratio of 1.36 (95% confidence interval, 1.01 to 1.81).

Conclusions: Analyses of our recent regional experience with nonemergent CABG showed that a prior cardiac operation was associated with a nearly twofold increased hazard of death at up to 4 years of follow-up.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cardiac Surgical Procedures
  • Coronary Artery Bypass / mortality*
  • Coronary Artery Disease / mortality
  • Coronary Artery Disease / surgery*
  • Female
  • Follow-Up Studies
  • Hospital Mortality / trends
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • New England / epidemiology
  • Postoperative Period
  • Propensity Score
  • Prospective Studies
  • Risk Assessment
  • Risk Factors
  • Survival Rate / trends
  • Time Factors