Acute and long-term safety of external trigeminal nerve stimulation for drug-resistant epilepsy

Epilepsy Behav. 2011 Nov;22(3):574-6. doi: 10.1016/j.yebeh.2011.06.024. Epub 2011 Sep 29.


Trigeminal nerve stimulation (TNS) is a novel therapy for drug-resistant epilepsy. We report in detail the safety of external TNS (eTNS), focusing on acute and long-term heart rate and systolic and diastolic blood pressure in response to TNS from the pilot feasibility study. The data indicate that eTNS of the infraorbital and supraorbital branches of the trigeminal nerve is safe and well tolerated.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Analysis of Variance
  • Blood Pressure / physiology
  • Electric Stimulation Therapy / methods*
  • Epilepsy / therapy*
  • Follow-Up Studies
  • Heart Rate / physiology
  • Humans
  • Middle Aged
  • Time Factors
  • Trigeminal Nerve / physiology*
  • Young Adult