Determinants and risk factors for central corneal thickness in Japanese persons: the Funagata Study

Ophthalmic Epidemiol. 2011 Oct;18(5):244-9. doi: 10.3109/09286586.2011.594206.


Purpose: To examine the association between glucose metabolism and central corneal thickness (CCT) in Japanese adults.

Methods: A sub-sample of 322 Japanese adults participating in the Funagata Study was included in this analysis. CCT was measured using a specular microscope. Glucose metabolism was examined using 75-g oral glucose tolerance test. Mean differences in CCT (μm) and 95% confidence intervals were estimated with univariate, age-sex-adjusted and multivariate models using multiple linear regression.

Results: The mean (± standard deviation) age of the study sample was 63.7 ± 11.4 years and 44% were men. The mean fasting plasma glucose (FPG), 2-hour post-load plasma glucose (2hPG) and haemoglobin A1c (HbA1c) concentrations were 96.8 ± 12.6mg/dl, 123.6 ± 41.2mg/dl and 5.3 ± 0.4%, respectively. CCT was normally distributed in the study sample, and the mean CCT was 544.7 ± 34.6μm. After multivariate adjustment, characteristics associated with increased CCT were 2hPG and HbA1c concentrations, impaired glucose tolerance, diabetes, body weight or body mass index and current smoking.

Conclusion: Impaired glucose tolerance, diabetes, obesity and current smoking are associated with increased CCT. Additional studies are required to examine whether interventions to affect these characteristics may reduce CCT.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Blood Glucose / metabolism*
  • Cornea / anatomy & histology*
  • Diabetes Mellitus / physiopathology
  • Female
  • Glucose Intolerance / physiopathology
  • Glucose Tolerance Test
  • Glycated Hemoglobin A / analysis
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Risk Factors


  • Blood Glucose
  • Glycated Hemoglobin A