FOXP1 and PAX5 are rare but recurrent translocations partners in acute lymphoblastic leukemia

Cancer Genet. 2011 Aug;204(8):462-4. doi: 10.1016/j.cancergen.2011.07.006.

Abstract

Here, we report the case of a 57-year-old man, who was diagnosed with B-cell acute lymphoblastic leukemia (B-ALL). His diagnostic workup identified a translocation t(3;9)(p13;p13). This is the fifth case reported to date that involved the forkhead box P1 gene (FOXP1) and paired box gene 5 (PAX5). The PAX5-FOXP1 translocation is a nonrandom aberration, which is recurrent in both childhood and in adult B-ALL, and may contribute to leukemogenesis by blocking differentiation of hematopoietic cells into mature B-cells.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • B-Lymphocytes / pathology
  • Chromosomes, Human, Pair 3 / genetics*
  • Chromosomes, Human, Pair 9 / genetics*
  • Forkhead Transcription Factors / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Middle Aged
  • Oncogene Proteins, Fusion / genetics
  • PAX5 Transcription Factor / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Repressor Proteins / genetics*
  • Translocation, Genetic / genetics*

Substances

  • FOXP1 protein, human
  • Forkhead Transcription Factors
  • Oncogene Proteins, Fusion
  • PAX5 Transcription Factor
  • PAX5 protein, human
  • Repressor Proteins