Short duration transcranial direct current stimulation (tDCS) modulates verbal memory

Brain Stimul. 2012 Oct;5(4):468-74. doi: 10.1016/j.brs.2011.08.003. Epub 2011 Aug 25.


Transcranial direct current stimulation (tDCS) is a noninvasive method of modulating cortical excitability. The aim of this study was to investigate the effects of short-duration tDCS (1.6 seconds per trial) on memory performance, and whether the effects were affected by stimulation administered early or late in a trial. Participants memorize words under anodal and cathodal tDCS to the left dorsolateral prefrontal cortex (DLPFC) in two separate sessions in no-stimulation, early stimulation, and late stimulation trials. Early stimulation occurred during word presentation, whereas late stimulation occurred after word presentation. Early anodal tDCS led to significantly better accuracy and speed in a subsequent recognition test compared to anodal late or no-stimulation conditions. Early cathodal tDCS, on the other hand, led to significantly worse accuracy and speed in a subsequent recognition test compared with cathodal late or no-stimulation conditions. The results of this study suggest that short-duration tDCS can modulate memory performance and highlight the importance of period of stimulation.

MeSH terms

  • Adolescent
  • Adult
  • Electric Stimulation
  • Female
  • Humans
  • Male
  • Memory / physiology*
  • Neuropsychological Tests
  • Prefrontal Cortex / physiology*
  • Reaction Time / physiology
  • Recognition, Psychology / physiology
  • Speech / physiology*