Evaluation of bee venom and hyaluronic acid in the intra-articular treatment of osteoarthritis in an experimental rabbit model

Res Vet Sci. 2012 Aug;93(1):488-93. doi: 10.1016/j.rvsc.2011.08.007. Epub 2011 Sep 29.

Abstract

The aim of this study was to investigate bee venom and hyaluronic acid in the intra-articular treatment of osteoarthritis in an experimental rabbit model. Forty-five rabbits were used and they were randomly divided into three groups (BVI, BVII, and HA) and each group was divided to two subgroups to evaluate the radiologic, magnetic resonance imaging, histopathologic, and biochemical evaluation in post treatment second week (a) and twelfth week (b). Radiologically, a significant difference was observed in the HA group (P<0.05). The MRI evaluation of at any time in group BVI(b) was found to be different. No significant differences were seen between the groups, biochemically. Histopathologically, cellularity, and orthochromasia was evident with Safranin-O in the BVI(b) and BVII(a); adhesions were seen in the BVII(a) group and clustering of chondrocyte in the HA(b) group were found to be different. Consequently, intra-articular application of HA and BV for experimental model of osteoarthritis has no significant influence upon recovery after therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine Transaminase / blood
  • Animals
  • Aspartate Aminotransferases / blood
  • Bee Venoms / administration & dosage
  • Bee Venoms / therapeutic use*
  • Blood Proteins / analysis
  • Blood Urea Nitrogen
  • Creatinine / blood
  • Disease Models, Animal
  • Drug Therapy, Combination
  • Hyaluronic Acid / administration & dosage
  • Hyaluronic Acid / therapeutic use*
  • Injections, Intra-Articular / veterinary
  • L-Lactate Dehydrogenase / blood
  • Magnetic Resonance Imaging
  • Male
  • Osteoarthritis / diagnostic imaging
  • Osteoarthritis / drug therapy*
  • Osteoarthritis / ethnology
  • Osteoarthritis / pathology
  • Rabbits
  • Radiography

Substances

  • Bee Venoms
  • Blood Proteins
  • Hyaluronic Acid
  • Creatinine
  • L-Lactate Dehydrogenase
  • Aspartate Aminotransferases
  • Alanine Transaminase