Spatial frequency threshold and contrast sensitivity of an optomotor behavior are impaired in the Ins2Akita mouse model of diabetes

Behav Brain Res. 2012 Jan 15;226(2):601-5. doi: 10.1016/j.bbr.2011.09.030. Epub 2011 Sep 28.


Diabetic retinopathy can lead to progressive loss of vision and is a leading cause of blindness. The Ins2(Akita) mouse model of diabetes develops significant retinal and systemic pathology, but how these affect visual behavior is unknown. Here, we show that Ins2(Akita) mice have progressive, quantifiable vision deficits in an optomotor behavior. This mouse line is a promising model in which to understand the contribution of retinal neuronal injury during the chronic hyperglycemia and hypoinsulinemia of diabetes to deficits in vision.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Contrast Sensitivity*
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / genetics
  • Diabetes Mellitus, Experimental / psychology*
  • Diabetic Retinopathy / blood
  • Diabetic Retinopathy / genetics
  • Diabetic Retinopathy / psychology*
  • Insulin / genetics*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Photic Stimulation / methods
  • Psychomotor Performance
  • Vision, Ocular / genetics
  • Visual Perception / genetics*


  • Blood Glucose
  • Insulin