Treatment of a large corneal perforation with a multilayer of amniotic membrane and TachoSil

Cornea. 2012 Jan;31(1):98-100. doi: 10.1097/ICO.0b013e31821f28a2.


Objective: To describe a novel surgical technique for the sealing of large corneal perforations.

Method: Case report of a perforated, 3-mm, postherpetic, corneal ulcer. A single layer of amniotic membrane was sewn to the internal surface of the cornea. An absorbable fibrin sealant patch (TachoSil) was placed in the area of the perforation, and a folded double layer of amniotic membrane was finally sewn to the external face of the cornea.

Result: Surgery without complications, leading to restoration of the anterior chamber and good subjective tolerance.

Conclusion: The reported technique seems to represent a good alternative emergency procedure for the management of corneal perforations larger than 2 mm.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amnion / transplantation*
  • Corneal Perforation / surgery*
  • Corneal Ulcer / surgery
  • Drug Combinations
  • Fibrin Tissue Adhesive / therapeutic use*
  • Fibrinogen / therapeutic use*
  • Humans
  • Keratitis, Herpetic / complications
  • Male
  • Thrombin / therapeutic use*
  • Treatment Outcome


  • Drug Combinations
  • Fibrin Tissue Adhesive
  • TachoSil
  • Fibrinogen
  • Thrombin