MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis

J Immunol. 2011 Nov 1;187(9):4695-704. doi: 10.4049/jimmunol.1101776. Epub 2011 Sep 30.


Dysregulation of the T cell-dependent Ab response can lead to numerous immunological disorders, ranging from systemic lupus erythematosus to B cell lymphomas. Cellular processes governed by MHC class II proteins play a major role in this response and its dysregulation. The extent to which processes controlled by the diverse family of MHC class I proteins impact such autoimmune and neoplastic disorders, however, is less clear. In this study, we genetically dissect the contributions of individual MHC class I family members and the pathological processes under their control in the systemic lupus erythematosus-like disease of BXSB.Yaa mice and B cell lymphomagenesis of SJL mice. This study reveals a powerful repressive regulatory axis comprised of MHC class I-dependent CD8(+) T cells and NK cells. These results indicate that the predominant role of the MHC class I protein family in such immunological disorders is to protect from more aggressive diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocyte Subsets / immunology*
  • B-Lymphocyte Subsets / pathology*
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / pathology
  • CD8-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / pathology
  • H-2 Antigens / genetics
  • Histocompatibility Antigen H-2D
  • Histocompatibility Antigens Class I / genetics
  • Histocompatibility Antigens Class I / physiology*
  • Killer Cells, Natural / immunology
  • Killer Cells, Natural / pathology
  • Lupus Erythematosus, Systemic / immunology*
  • Lupus Erythematosus, Systemic / mortality
  • Lupus Erythematosus, Systemic / prevention & control*
  • Lymphoma, B-Cell / immunology*
  • Lymphoma, B-Cell / mortality
  • Lymphoma, B-Cell / prevention & control*
  • Mice
  • Mice, Inbred Strains
  • Moloney murine leukemia virus / immunology
  • beta 2-Microglobulin / deficiency
  • beta 2-Microglobulin / genetics


  • H-2 Antigens
  • H-2K(K) antigen
  • Histocompatibility Antigen H-2D
  • Histocompatibility Antigens Class I
  • beta 2-Microglobulin