Mechanisms by which EGF receptor and TGF alpha contribute to malignant transformation

Nat Immun Cell Growth Regul. 1990;9(3):209-21.


Alterations affecting the epidermal growth factor/transforming growth factor alpha-responsive mitogenic pathway are frequently detected in malignancies. In particular, the epidermal growth factor receptor has been found overexpressed in a number of human tumors. Production and secretion of transforming growth factor type alpha has also been shown in several tumor cells but not in their normal counterparts. In this review we describe the establishment of in vitro model systems to study the transforming potential of these molecules and summarize our current understanding of the mechanisms involved in transformation by genes encoding a growth factor and a growth factor receptor.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division
  • Cell Line
  • Cell Transformation, Neoplastic / genetics*
  • ErbB Receptors / genetics
  • ErbB Receptors / physiology*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Oncogenes
  • Transfection
  • Transforming Growth Factors / genetics
  • Transforming Growth Factors / physiology*


  • Transforming Growth Factors
  • ErbB Receptors