Effects of Cytokinins, Cytokinin Ribosides and Their Analogs on the Viability of Normal and Neoplastic Human Cells

Anticancer Res. 2011 Oct;31(10):3401-6.

Abstract

We examined the effects of some cytokinins and cytokinin ribosides including a series of adenosine analogs differently substituted in the N(6) position, along with some hypoxanthine derivatives on the viability of normal and neoplastic human cells. Cytokinins such as trans-zeatin, isopentenyladenine and benzyladenine do not show any effect, while cytokinin ribosides such as trans-zeatin riboside, isopentenyladenosine, and benzylaminopurine riboside impair the viability of normal and neoplastic cells, apart from colon carcinoma LoVo cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / analogs & derivatives
  • Adenosine / chemistry
  • Adenosine / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cisplatin / pharmacology
  • Cytokinins / chemistry
  • Cytokinins / pharmacology*
  • Drug Resistance, Neoplasm / drug effects
  • Drug Screening Assays, Antitumor
  • Humans
  • Isopentenyladenosine / analogs & derivatives
  • Isopentenyladenosine / chemistry
  • Isopentenyladenosine / pharmacology
  • Neoplasms / pathology*
  • Neutral Red / metabolism
  • Ribonucleosides / chemistry
  • Ribonucleosides / pharmacology*
  • Tumor Stem Cell Assay
  • Zeatin / analogs & derivatives
  • Zeatin / chemistry

Substances

  • Cytokinins
  • Ribonucleosides
  • Neutral Red
  • N(6)-benzyladenosine
  • Isopentenyladenosine
  • Zeatin
  • zeatin riboside
  • Adenosine
  • Cisplatin