Potential Effect of Bacopa monnieri on Nitrobenzene Induced Liver Damage in Rats

Indian J Clin Biochem. 2010 Oct;25(4):401-4. doi: 10.1007/s12291-010-0048-4. Epub 2010 Sep 14.


The study was designed to evaluate the hepatoprotective activity of ethanolic extract of Bacopa monnieri in acute experimental liver injury induced by Nitrobenzene in rats. The extract at the dose of 200 mg/kg body weight was administered orally once every day for 10 days. The increased serum marker enzymes, Aspartate transaminase, Alanine transaminase and alkaline phosphatase were restored towards normalization significantly by the extract. Significant increase in SOD, CAT and GPx was observed in extract treated liver injured experimental rats. Histopathological examination of the liver tissues supported the hepatoprotection. It is concluded that the ethanolic extract of Bacopa monieri plant possess good hepatoprotective activity.

Keywords: Antioxidants; Hepatoprotective effect; Liver marker enzymes.