Weight gain since menopause and its associations with weight loss maintenance in obese postmenopausal women

Clin Interv Aging. 2011;6:221-5. doi: 10.2147/CIA.S23574. Epub 2011 Aug 19.


Objective: To examine the association between weight gain since menopause and weight regain after a weight loss program.

Methods: Participants were 19 obese women who participated in a 15-week weight loss program and a 12-month follow-up. Main outcomes were: body composition, resting metabolic rate, energy intake, energy expenditure, and weight regain at follow-up.

Results: All body composition measures significantly decreased after intervention (all P ≤ 0.01) while all measures of fatness increased significantly after the 12-month follow-up (P ≤ 0.01). Body weight gain since menopause was associated with body weight regain (r = 0.65; P = 0.003) after follow-up even after adjustment for confounders.

Conclusion: Weight gain since menopause is associated with body weight regain following the weight loss program. Therefore, weight gain since menopause should be considered as a factor influencing weight loss maintenance in older women.

Keywords: aging; body weight; obesity; postmenopausal women; weight regain.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Basal Metabolism / physiology
  • Body Composition / physiology
  • Caloric Restriction
  • Diet, Reducing / statistics & numerical data*
  • Female
  • Follow-Up Studies
  • Humans
  • Menopause / metabolism*
  • Middle Aged
  • Obesity / diet therapy*
  • Obesity / epidemiology
  • Obesity / metabolism*
  • Postmenopause / metabolism*
  • Prevalence
  • Risk Factors
  • Treatment Failure
  • Weight Gain / physiology*