Childhood epidermolysis bullosa acquisita: report of a Chinese case

Pediatr Dermatol. 2012 Sep-Oct;29(5):614-7. doi: 10.1111/j.1525-1470.2011.01509.x. Epub 2011 Oct 4.

Abstract

Epidermolysis bullosa acquisita (EBA) is a rare, acquired, subepidermal blistering disease characterized by autoantibodies directed against type VII collagen, the major component of anchoring fibrils. We report a 5-year-old Chinese boy who presented with extensive lesions consisting of disseminated pruritic vesicles and tense blisters. The diagnosis of EBA was confirmed by histopathology, immunofluorescence, and immunoblotting analysis. The disease was controlled with a combination of prednisone and dapsone.

Publication types

  • Case Reports

MeSH terms

  • Asian People
  • Autoantibodies / blood
  • Autoantibodies / immunology
  • Basement Membrane / immunology
  • Child, Preschool
  • Collagen Type VII / immunology
  • Dapsone / therapeutic use
  • Dermatologic Agents / therapeutic use
  • Drug Therapy, Combination
  • Epidermolysis Bullosa Acquisita / diagnosis*
  • Epidermolysis Bullosa Acquisita / drug therapy
  • Epidermolysis Bullosa Acquisita / pathology
  • Fluorescent Antibody Technique
  • Humans
  • Immunoblotting
  • Male
  • Prednisone / therapeutic use
  • Treatment Outcome

Substances

  • Autoantibodies
  • Collagen Type VII
  • Dermatologic Agents
  • Dapsone
  • Prednisone