Chronic necrotizing pulmonary aspergillosis treated by endobronchial amphotericin B

South Med J. 1990 Jul;83(7):829-32. doi: 10.1097/00007611-199007000-00025.


Chronic necrotizing pulmonary aspergillosis is an indolent, locally invasive form of Aspergillus infection. Treatment options are limited and controversial. Resection is often curative if the patient has sufficient ventilatory reserve. Even though intravenous amphotericin B is effective in a few patients, toxicity limits its use. Aerosolized amphotericin B has proven ineffective. Anecdotal reports of intracavitary and endobronchial antifungal therapy show limited success. Our patient had unresectable chronic necrotizing pulmonary aspergillosis treated successfully with intracavitary instillation of amphotericin B, delivered via the flexible fiberoptic bronchoscope.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Amphotericin B / administration & dosage
  • Amphotericin B / therapeutic use*
  • Aspergillosis / diagnostic imaging
  • Aspergillosis / drug therapy*
  • Aspergillosis / pathology
  • Bronchoscopy
  • Chronic Disease
  • Humans
  • Infusions, Parenteral
  • Lung Diseases, Fungal / diagnostic imaging
  • Lung Diseases, Fungal / drug therapy*
  • Lung Diseases, Fungal / pathology
  • Male
  • Middle Aged
  • Necrosis
  • Radiography


  • Amphotericin B