Rational polytherapy in the treatment of acute seizures and status epilepticus

Epilepsia. 2011 Oct;52 Suppl 8(0 8):70-1. doi: 10.1111/j.1528-1167.2011.03243.x.

Abstract

We used a model of severe cholinergic status epilepticus (SE) to study polytherapy aimed at reversing the effects of seizure-induced loss of synaptic GABA(A) receptors and seizure-induced gain of synaptic NMDA receptors. Combinations of a benzodiazepine with ketamine and valproate, or with ketamine and brivaracetam, were more effective and less toxic than benzodiazepine monotherapy in this model of SE.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anticonvulsants / therapeutic use*
  • Disease Models, Animal
  • Drug Therapy, Combination / methods*
  • Humans
  • Seizures / drug therapy*
  • Status Epilepticus / drug therapy*

Substances

  • Anticonvulsants