The relationship between mean pulmonary artery pressure and quality of life in patients with mitral stenosis

Cardiology. 2011;119(3):170-5. doi: 10.1159/000331435. Epub 2011 Sep 28.


Objectives: We aimed to evaluate echocardiography-guided hemodynamic determinants of quality of life (QoL) via the Medical Outcomes Study Short Form (SF-36) questionnaire in patients with mild to moderate mitral stenosis (MS).

Methods: Eighty consecutive patients with rheumatic MS, who were admitted to the outpatient department, were enrolled into the study upon obtaining informed consent. Forty age-sex-matched healthy individuals were enrolled as a control group.

Results: All subscale scores and total SF-36 scores were significantly lower in the patient group representing a worse QoL. In multivariable logistic regression analysis, only mean pulmonary artery pressure (OR 1.138, 95% CI 1.049-1.234, p = 0.002) was found to be an independent predictor of poor QoL in patients with mild to moderate MS.

Conclusion: During follow-up of MS patients before intervention, physicians should consider that mean pulmonary artery pressure is the main factor which influences the patients' QoL. In patients with MS, it seems that referral to intervention should consider components and derivatives of QoL.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Case-Control Studies
  • Echocardiography, Doppler
  • Female
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Mitral Valve Stenosis / diagnosis*
  • Mitral Valve Stenosis / psychology
  • Multivariate Analysis
  • Predictive Value of Tests
  • Prognosis
  • Pulmonary Wedge Pressure*
  • Quality of Life*
  • Reference Values
  • Risk Assessment
  • Severity of Illness Index
  • Sickness Impact Profile
  • Statistics, Nonparametric
  • Surveys and Questionnaires