A brief history of error

Nat Cell Biol. 2011 Oct 3;13(10):1178-82. doi: 10.1038/ncb2348.


The spindle checkpoint monitors chromosome alignment on the mitotic and meiotic spindle. When the checkpoint detects errors, it arrests progress of the cell cycle while it attempts to correct the mistakes. This perspective will present a brief history summarizing what we know about the checkpoint, and a list of questions we must answer before we understand it.

Publication types

  • Historical Article
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cell Biology / history*
  • Cell Cycle Checkpoints
  • Cell Cycle* / genetics
  • Chromosomes* / metabolism
  • DNA Damage*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Signal Transduction
  • Spindle Apparatus* / metabolism