Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review

BMC Cancer. 2011 Oct 4;11:423. doi: 10.1186/1471-2407-11-423.

Abstract

Background: Chordomas are very rare low-grade malignant bone tumors that arise from the embryonic rests of the notochord. They are characterized by slow growth and long history with frequent local relapses, and sometimes metastases. While chemotherapy is not efficient, imatinib has shown antitumor activity.

Case presentation: We report on a 76-year-old patient with EGFR-overexpressing advanced chordoma that progressed on imatinib and subsequently responded to erlotinib during 12 months.

Conclusions: We report the fourth case of advanced chordoma treated with an EGFR inhibitor. We also review the literature concerning the rationale and potential of EGFR targeting in chordoma.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aged
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / therapeutic use*
  • Benzamides
  • Bone Neoplasms / drug therapy*
  • Bone Neoplasms / pathology
  • Chordoma / drug therapy*
  • Chordoma / pathology
  • ErbB Receptors / antagonists & inhibitors*
  • Erlotinib Hydrochloride
  • Humans
  • Imatinib Mesylate
  • Male
  • Molecular Targeted Therapy
  • Neoplasm Staging
  • Piperazines / administration & dosage
  • Piperazines / therapeutic use
  • Protein Kinase Inhibitors / administration & dosage
  • Protein Kinase Inhibitors / therapeutic use*
  • Pyrimidines / administration & dosage
  • Pyrimidines / therapeutic use
  • Quinazolines / administration & dosage
  • Quinazolines / therapeutic use
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Benzamides
  • Piperazines
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Quinazolines
  • Imatinib Mesylate
  • Erlotinib Hydrochloride
  • ErbB Receptors