Sodium-coupled chloride transport by epithelial tissues

Am J Physiol. 1979 Jan;236(1):F1-8. doi: 10.1152/ajprenal.1979.236.1.F1.


There is compelling evidence that active Cl absorption by a variety of epithelia, widely distributed throughout the animal kingdom, is the result of an electrically neutral Na-coupled transport process at the luminal membrane and that the energy for transcellular Cl movement is derived from the Na gradient across that barrier. These co-transport processes are found predominantly in "leaky" or "moderately leaky" epithelia and permit these tissues to absorb Na and Cl with high degrees of efficacy. In addition, there is a growing body of evidence that cyclic AMP and Ca-induced electrogenic Cl secretion by a wide variety of epithelia may involve electrically neutral, Na-coupled Cl entry across the contraluminal membrane and that the energy for these secretory processes is derived from the Na-gradient across that barrier. A model for electrogenic Cl secretion that accounts for the available data is presented.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Absorption
  • Animals
  • Biological Transport, Active
  • Chlorides / metabolism*
  • Choline / pharmacology
  • Cyclic AMP / metabolism
  • Electrophysiology
  • Epithelium / metabolism*
  • Furosemide / pharmacology
  • Gallbladder / metabolism
  • Intestinal Mucosa / metabolism
  • Membrane Potentials
  • Models, Biological
  • Skin / metabolism
  • Sodium / metabolism*
  • Urinary Bladder / metabolism


  • Chlorides
  • Furosemide
  • Sodium
  • Cyclic AMP
  • Choline