Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia

Psychiatr Genet. 2012 Feb;22(1):1-14. doi: 10.1097/YPG.0b013e32834c0c33.


Objective: The chromosomal region, 15q13-q14, including the α7 nicotinic acetylcholine receptor gene, CHRNA7, is a replicated region for schizophrenia. This study fine-mapped genes at 15q13-q14 to determine whether the association is unique to CHRNA7.

Methods: Family-based and case-control association studies were performed on Caucasian-non-Hispanic and African-American individuals from 120 families as well as 468 individual patients with schizophrenia and 144 well-characterized controls. Single-nucleotide polymorphism (SNP) markers were genotyped, and association analyses carried out for the outcomes of schizophrenia, smoking, and smoking in schizophrenia.

Results: Three genes were associated with schizophrenia in both ethnic populations: TRPM1, KLF13, and RYR3. Two SNPs in CHRNA7 were associated with schizophrenia in African-Americans, and a second SNP in CHRNA7 was significant for an association with smoking and smoking in schizophrenia in Caucasians.

Conclusion: Results of these studies support association of the 15q13-q14 region with schizophrenia. The broad positive association suggests that more than one 15q gene may be contributing to the disorder, either in combination or through a regulatory mechanism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Black or African American / genetics
  • Case-Control Studies
  • Chromosomes, Human, Pair 15 / genetics*
  • Family
  • Genetic Association Studies*
  • Genetic Linkage
  • Genetic Markers
  • Genetic Predisposition to Disease*
  • Genotyping Techniques
  • Hispanic or Latino / genetics
  • Humans
  • Microsatellite Repeats / genetics
  • Odds Ratio
  • Physical Chromosome Mapping
  • Polymorphism, Single Nucleotide / genetics
  • Schizophrenia / genetics*
  • Smoking / genetics
  • White People / genetics


  • Genetic Markers