Prognostic value of chemotherapy-induced neutropenia in early-stage breast cancer

Breast Cancer Res Treat. 2012 Jan;131(2):483-90. doi: 10.1007/s10549-011-1799-1. Epub 2011 Oct 5.


Neutropenia is one of the most important dose-limiting toxicities and often the reason for dose reduction. In this study we aimed to assess whether chemotherapy-induced neutropenia could be a marker of efficacy and associate with increased survival. Data from a retrospective survey for early breast cancer patients in our hospital were reviewed. Three hundred and thirty-five patients who had been treated with six cycles of cyclophosphamide, epirubicin, and fluorouracil (CEF) were studied. The association between chemotherapy-induced neutropenia and overall survival (OS) was assessed. According to a multivariate Cox model with time-varying covariates, hazard ratios of death were 0.434 (95% confidence interval (CI), 0.298-0.634; P < 0.001) for patients with mild neutropenia, and 0.640 (95% CI, 0.42-0.975; P = 0.038) for those with severe neutropenia. Neutropenia occurring in early breast cancer patients is an independent predictor of increased survival. These findings suggest that neutropenia in patients who receive chemotherapy is strongly associated with a better prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Breast Neoplasms / complications*
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / mortality
  • Chemotherapy, Adjuvant
  • Female
  • Humans
  • Incidence
  • Middle Aged
  • Neoplasm Staging
  • Neutropenia / chemically induced*
  • Neutropenia / epidemiology
  • Prognosis
  • Survival Analysis
  • Time Factors


  • Antineoplastic Agents