European dissemination of a single OXA-48-producing Klebsiella pneumoniae clone

Clin Microbiol Infect. 2011 Dec;17(12):E24-6. doi: 10.1111/j.1469-0691.2011.03669.x. Epub 2011 Oct 6.


A Klebsiella pneumoniae isolate with decreased susceptibility to carbapenems was isolated in April 2011 in a hospital in Amsterdam (the Netherlands) and later found to be the source of an important outbreak in a Rotterdam hospital. The strain, belonging to sequence type (ST) 395, carried the bla(OXA-48) gene located onto a c 62-kb conjugative plasmid, together with the extended-spectrum β-lactamase gene bla(CTX-M-15) . It was closely related or identical to other OXA-48-positive Klebsiella pneumoniae isolates belonging to the same ST type and identified in France and Morocco. This study sheds light on the European dissemination of a single OXA-48 K. pneumoniae clone.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cluster Analysis
  • Disease Outbreaks*
  • France / epidemiology
  • Genotype
  • Humans
  • Klebsiella Infections / epidemiology*
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / genetics*
  • Klebsiella pneumoniae / isolation & purification
  • Male
  • Molecular Epidemiology
  • Molecular Typing*
  • Morocco / epidemiology
  • Netherlands / epidemiology
  • Plasmids / analysis
  • Polymerase Chain Reaction
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism


  • beta-Lactamases
  • oxacillinase