Current status of leprosy: epidemiology, basic science and clinical perspectives

J Dermatol. 2012 Feb;39(2):121-9. doi: 10.1111/j.1346-8138.2011.01370.x. Epub 2011 Oct 4.


Leprosy has affected humans for millennia and remains an important health problem worldwide, as evidenced by nearly 250 000 new cases detected every year. It is a chronic infectious disorder, caused by Mycobacterium leprae, that primarily affects the skin and peripheral nerves. Recent advances in basic science have improved our knowledge of the disease. Variation in the cellular immune response is the basis of a range of clinical manifestations. The introduction of multidrug therapy has significantly contributed to a decrease in the prevalence of the disease. However, leprosy control activities, including monitoring and prevention programs, must be maintained.

Publication types

  • Review

MeSH terms

  • Animals
  • Dapsone / therapeutic use
  • Drug Therapy, Combination
  • Female
  • Humans
  • Leprostatic Agents / therapeutic use
  • Leprosy* / drug therapy
  • Leprosy* / epidemiology
  • Leprosy* / pathology
  • Leprosy* / transmission
  • Male
  • Mycobacterium leprae* / cytology
  • Mycobacterium leprae* / drug effects
  • Mycobacterium leprae* / isolation & purification
  • Peripheral Nervous System Diseases / microbiology
  • Prevalence
  • Treatment Outcome


  • Leprostatic Agents
  • Dapsone