Preoperative Immunostimulation With Propionibacterium Avidum KP-40 in Patients With Gastric Carcinoma: A Prospective Randomized Study

Onkologie. 1990 Apr;13(2):124-7. doi: 10.1159/000216738.

Abstract

Sixty-eight patients admitted for resection of gastric carcinoma entered a prospectively randomized trial. Patients in the therapy group (n = 34) received a preoperative controlled infusion of 10 mg Propionibacterium avidum KP-40. The therapy and control group did not differ with regard to postoperative complications, tumor recurrence rates (therapy group: 41%, control group: 38%), and patient survival rates (survival rate in the therapy group after 25 months: 53%, in the control group after 25 months: 50%).

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adenocarcinoma / immunology
  • Adenocarcinoma / surgery
  • Adenocarcinoma / therapy*
  • Adjuvants, Immunologic / administration & dosage*
  • Adult
  • Aged
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Gastrectomy
  • Humans
  • Hypersensitivity, Delayed / immunology
  • Immune Tolerance / immunology
  • Immunotherapy / methods*
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / immunology
  • Propionibacterium / immunology*
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Stomach Neoplasms / immunology
  • Stomach Neoplasms / surgery
  • Stomach Neoplasms / therapy*

Substances

  • Adjuvants, Immunologic