Regulatory gene network circuits underlying T cell development from multipotent progenitors

Wiley Interdiscip Rev Syst Biol Med. Jan-Feb 2012;4(1):79-102. doi: 10.1002/wsbm.162. Epub 2011 Oct 4.


Regulatory gene circuits enable stem and progenitor cells to detect and process developmental signals and make irreversible fate commitment decisions. To gain insight into the gene circuits underlying T cell fate decision making in progenitor cells, we generated an updated T-lymphocyte developmental gene regulatory network from genes and connections found in the literature. This reconstruction allowed us to identify candidate regulatory gene circuit elements underlying T cell fate decision making. Here, we examine the roles of these circuits in facilitating different aspects of the decision making process, and discuss experiments to further probe their structure and function.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation / physiology*
  • Gene Regulatory Networks*
  • Humans
  • Interleukin-7 / physiology
  • Lymphocyte Activation / genetics
  • Lymphocyte Activation / physiology*
  • Mice
  • Models, Biological
  • Multipotent Stem Cells / physiology*
  • Receptors, Notch / physiology
  • Signal Transduction / physiology
  • T-Lymphocytes / physiology*


  • Interleukin-7
  • Receptors, Notch