Background: Glioma is a deadly neurological tumor. For modern management of glioma, glioma vaccinotherapy is the new concept.
Materials and methods: Based on present biomedical technique, the identification of T-cell epitopes via MHC mapping can help clarify the inter-relationship of tumor and immune system. This process can be performed using advanced immunoinformatics technique.
Results: Here, the author performs an immunoinformatics analysis to find alternative epitopes for glioma-related antigen, EPHA2.
Conclusion: After complete manipulation on EPHA2 molecules, the five best epitopes were derived.
Keywords: Epitope; T cell; glioma; vaccine.