p53 and BCL-2 over-expression inversely correlates with histological differentiation in occupational ethmoidal intestinal-type sinonasal adenocarcinoma

Int J Immunopathol Pharmacol. Jul-Sep 2011;24(3):603-9. doi: 10.1177/039463201102400306.

Abstract

Despite their histological resemblance to colorectal adenocarcinoma, there is little information on the molecular events involved in the pathogenesis of intestinal-type sinonasal adenocarcinoma (ITACs). The aim of this paper is to evaluate the possible role of TP53 and Bcl-2 gene defects in ITAC by investigating the immunohistochemical expression of TP53 and Bcl-2 gene products in a group of ethmoidal ITACs associated with occupational exposure. A retrospective study on 15 patients with pathological diagnosis of primary ethmoidal ITAC was conducted. Representative formalin-fixed, paraffin wax-embedded block from each case was selected for immunohistochemical studies using the antibodies against p53 and Bcl-2. Clinical-pathological data were also correlated with the staining results. The results of immunohistochemical examination demonstrated that poorly differentiated cases showed a higher percentage of p53 and Bcl-2 expressing cells in comparison to well-differentiated cases. No correlation was found with other clinico-pathological parameters, including T, stage and relapses. The relationship between up-regulation of p53 and Bcl-2 and poorly differentiated ethmoidal adenocarcinoma suggests a role of these genes, in combination with additional genetic events, in the pathogenesis of ITAC.

MeSH terms

  • Adenocarcinoma / chemically induced*
  • Adenocarcinoma / genetics*
  • Adenocarcinoma / pathology
  • Aged
  • Biomarkers, Tumor
  • Dust
  • Female
  • Gene Expression / physiology*
  • Genes, bcl-2 / genetics*
  • Genes, p53 / genetics*
  • Humans
  • Immunohistochemistry
  • Intestinal Neoplasms / chemically induced*
  • Intestinal Neoplasms / genetics*
  • Intestinal Neoplasms / pathology
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Nose Neoplasms / chemically induced*
  • Nose Neoplasms / genetics*
  • Nose Neoplasms / pathology
  • Occupational Diseases / chemically induced*
  • Occupational Diseases / genetics*
  • Occupational Diseases / pathology
  • Occupational Exposure / adverse effects
  • Paraffin Embedding
  • Paranasal Sinus Neoplasms / chemically induced*
  • Paranasal Sinus Neoplasms / genetics*
  • Paranasal Sinus Neoplasms / pathology
  • Prognosis
  • Retrospective Studies
  • Tissue Fixation
  • Wood

Substances

  • Biomarkers, Tumor
  • Dust